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Glucosamine and chondroitin are naturally occurring chemicals found in the joints of the human body. A combination of both these chemicals is often used for reducing the pain involved in cartilage degeneration of the joints, a condition which leads to pain and swelling of the joints, especially the knee. While glucosamine may also be effective in weight management and lens clouding of the eye, chondroitin may play a role in managing heart disease and elevated cholesterol.